Document Detail


Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls.
MedLine Citation:
PMID:  16154700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aerobic exercise has been shown to activate endogenous opioid and adrenergic systems and attenuate experimental pain in normal control subjects (NC). In contrast, fibromyalgia (FM) subjects' experimental pain ratings increase after aerobic exercise, suggestive of abnormal pain modulation. In order to determine whether central or peripheral mechanisms are predominantly involved in the abnormal pain modulation of FM patients, the effects of handgrip exercise on thermal (cutaneous) and mechanical (somatic) experimental pain was tested in local as well as remote body areas of FM and NC subjects. Supra-threshold thermal pain ratings and pressure pain thresholds over both forearms were obtained before and during 90 s of sustained 30% maximal voluntary contraction (MVC). This isometric exercise resulted in substantially decreased thermal pain ratings and increased mechanical thresholds in local as well as remote body areas in NC. Opposite effects were detected in FM patients. Thus, sustained local muscular contraction induced widespread pain inhibitory effects in NC. In contrast, the widespread hyperalgesic effects of exercise on FM patients clearly indicate altered central pain mechanisms. However, whether these exercise effects of FM patients result from abnormal descending inhibition or excessive activation of muscle nociceptive afferents needs to be addressed in future studies.
Authors:
Roland Staud; Michael E Robinson; Donald D Price
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-09-09
Journal Detail:
Title:  Pain     Volume:  118     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-08     Completed Date:  2006-07-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  176-84     Citation Subset:  IM    
Affiliation:
Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610-0221, USA. staudr@ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Exercise / physiology*
Female
Fibromyalgia / diagnosis,  physiopathology*,  therapy
Hand Strength / physiology
Humans
Hyperalgesia / diagnosis
Middle Aged
Muscle, Skeletal / injuries,  physiopathology
Neural Inhibition / physiology
Neurons, Afferent / physiology
Nociceptors / physiology
Pain / physiopathology*,  therapy
Pain Measurement
Pain Threshold / physiology
Physical Stimulation / methods
Grant Support
ID/Acronym/Agency:
NS-38767/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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