Document Detail

Isomaltulose Improves Glycaemia and Maintains Run Performance in Type 1 Diabetes.
MedLine Citation:
PMID:  22051571     Owner:  NLM     Status:  Publisher    
PURPOSE:: Individuals with type 1 diabetes (T1DM) are encouraged to reduce rapid-acting insulin and consume carbohydrates to prevent hypoglycemia during or after exercise. However, research comparing the metabolic and performance effects of different carbohydrates is limited. This study compared the alterations in metabolism and fuel oxidation in response to performance running following pre-exercise ingestion of isomaltulose or dextrose in T1DM. METHODS:: Following preliminary testing, on two occasions seven T1DM individuals consumed 0.6 body mass of either dextrose (DEX; GI 96), or isomaltulose (ISO; GI 32), two hours before a discontinuous, incremental run to 80 %VO2peak on a motorised treadmill followed by a 10 minute all-out performance test on a non-motorised treadmill. Blood glucose (BG), acid-base and cardio-respiratory parameters were measured for 2 hours before, during and after both run tests. Data (mean ± SEM) were analysed using repeated-measures ANOVA. RESULTS:: Pre-exercise BGAUC was lower under ISO in comparison with DEX (ISO +4.0 ± 0.3 vs. DEX +7.0 ± 0.6 mmol.l-1.hour-1, P<0.01). Resting blood lactate concentrations and rate of carbohydrate oxidation under ISO were greater than those elicited under DEX (P<0.05). There were no metabolic or cardio-respiratory differences between conditions in response to submaximal exercise in spite of lower blood glucose concentrations under ISO (P<0.05). T1DM individuals completed the same distance at the same speed over the 10 minute run test under both conditions (NS). CONCLUSION:: Consumption of isomaltulose alongside rapid-acting insulin reduction improves blood glucose responses to exercise and produces a similar high-intensity run performance compared with dextrose in T1DM individuals.
R M Bracken; R Page; B Gray; L P Kilduff; D J West; J W Stephens; S C Bain
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-2
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Sports and Exercise Science, College of Engineering, Swansea University, Swansea, UK 2Department of Sport and Exercise, School of Life Science, Northumbria University, Newcastleupon-Tyne, UK 3Diabetes Research Group, College of Medicine, Swansea University, Singleton Park, Swansea, UK.
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