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Isoleucine as a possible bridge between exogenous delivery and terrestrial enhancement of homochirality.
MedLine Citation:
PMID:  22968664     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report a highly enantioselective oligomerization of isoleucine stereomers in the salt-induced peptide formation reaction under plausibly prebiotic earth conditions. Up to 6.5-fold superiority in reactivity of L-isoleucine was observed, compared to its D-enantiomer, after 14 evaporation cycles in the presence of Cu(2+) and NaCl. Since isoleucine is among the proteinogenic amino acids that were found enantioenriched in meteorites, this present work may further correlate the extraterrestrial delivery and endogenous production of biological homochirality by virtue of a protein constituent rather than the rarely occurring α-methylated amino acids.
Authors:
Feng Li; Daniel Fitz; Bernd M Rode
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-12
Journal Detail:
Title:  Amino acids     Volume:  -     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Faculty of Chemistry and Pharmacy, Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 52a, 6020, Innsbruck, Austria.
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