| Isolation and structure elucidation of tumescenamides A and B, two peptides produced by Streptomyces tumescens YM23-260. | |
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MedLine Citation:
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PMID: 20606694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two peptides, tumescenamides A and B, were isolated from the fermentation broth of a marine bacterium, Streptomyces tumescens YM23-260. The structure of tumescenamide A was determined to be a cyclic depsipeptide consisting of α-amino-2-butenoic acid, tyrosine, valine, leucine and threonine, substituted with a 2,4-dimethylheptanoyl residue at the α-NH(2) position. Tumescenamide B possesses a 2,4,6-trimethylnonanoyl residue in place of the 2,4-dimethylheptanoyl substituent in tumescenamide A. Tumescenamide A induced reporter gene expression under the control of the insulin-degrading enzyme promoter. |
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Authors:
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Keiichiro Motohashi; Takashi Toda; Masayuki Sue; Kazuo Furihata; Yoshikazu Shizuri; Yoshihide Matsuo; Hiroaki Kasai; Kazuo Shin-ya; Motoki Takagi; Miho Izumikawa; Yukio Horikawa; Haruo Seto |
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Publication Detail:
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Type: Journal Article Date: 2010-07-07 |
Journal Detail:
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Title: The Journal of antibiotics Volume: 63 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 549-52 Citation Subset: IM |
Affiliation:
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Bioregulatory Lab, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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analysis Depsipeptides / chemistry*, isolation & purification*, pharmacology, secretion Genes, Reporter Insulysin / biosynthesis, genetics Luciferases / biosynthesis, genetics Magnetic Resonance Spectroscopy Molecular Structure Promoter Regions, Genetic Streptomyces / metabolism* Transcriptional Activation |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Depsipeptides; EC 1.13.12.-/Luciferases; EC 3.4.24.56/Insulysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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