Document Detail


Isolation of a simian immunodeficiency virus related to human immunodeficiency virus type 2 from a west African pet sooty mangabey.
MedLine Citation:
PMID:  1840620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two of 25 healthy pet sooty mangabey (SM) monkeys (Cercocebus atys) living in West Africa were seropositive by immunoblot when surveyed for antibody to simian immunodeficiency virus of macaques (SIVmac). SIVsmLIB1 was isolated from one of the pet sooty mangabeys. Nucleotide sequence data showed that this isolate is a member of the SIVsm/human immunodeficiecy virus type 2 (HIV-2)/SIVmac group of primate lentiviruses. Furthermore, sequence comparisons revealed extensive genetic diversity among SIVsm isolates similar to that observed previously in SIV isolates from naturally infected African green monkeys. These observations provide additional evidence for monkey-human cross-species transmission of SIVsm as the source of HIV-2 infection of human.
Authors:
P A Marx; Y Li; N W Lerche; S Sutjipto; A Gettie; J A Yee; B H Brotman; A M Prince; A Hanson; R G Webster
Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  65     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-19     Completed Date:  1991-08-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4480-5     Citation Subset:  IM; X    
Affiliation:
California Primate Research Center, University of California, Davis 95616.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M62651;  M63040;  M63041;  M63042;  M63043;  M63044;  M63045;  M63046;  M63047;  M63048
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Domestic
Antibodies, Viral / blood
Base Sequence
Cercopithecidae / microbiology*
Cross Reactions
DNA, Recombinant / chemistry
DNA, Viral / chemistry
Female
HIV-2 / classification*
Humans
Liberia
Macaca mulatta
Molecular Sequence Data
Oligonucleotides / chemistry
Polymerase Chain Reaction
Simian Acquired Immunodeficiency Syndrome / microbiology*
Simian immunodeficiency virus / classification,  genetics,  immunology,  isolation & purification*
Grant Support
ID/Acronym/Agency:
AI-27698/AI/NIAID NIH HHS; RR00168/RR/NCRR NIH HHS; RR00169/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Recombinant; 0/DNA, Viral; 0/Oligonucleotides
Comments/Corrections

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