| Isolation and primary structure of glucagon from the endocrine pancreas of Thunnus obesus. | |
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MedLine Citation:
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PMID: 1916209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucagon has been isolated from the endocrine pancreas of a tunid, Thunnus obesus. The primary structure of the glucagon molecule was established as H S E G T F S N D Y S K Y L E T R R A Q D F V Q W L K N S. The sequence is identical to those of sculpin and flounder glucagon and glucagon II from anglerfish. It also shows high homology to the mammalian hormone (76%). The mass determined by fast-atom bombardment (3508) was consistent with the proposed structure. Immunological properties of the tuna glucagon were analyzed by radioimmunoassay, showing a high degree of cross-reactivity with the 30K antibody. |
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Authors:
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I Navarro; J Gutiérrez; J Caixach; J Rivera; J Planas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: General and comparative endocrinology Volume: 83 ISSN: 0016-6480 ISO Abbreviation: Gen. Comp. Endocrinol. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-11-15 Completed Date: 1991-11-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370735 Medline TA: Gen Comp Endocrinol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 227-32 Citation Subset: IM |
Affiliation:
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Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Chromatography, Gel Chromatography, High Pressure Liquid Fishes / physiology Glucagon / chemistry*, isolation & purification Humans Islets of Langerhans / physiology* Molecular Sequence Data Radioimmunoassay Sequence Homology, Nucleic Acid Tuna / physiology* |
| Chemical | |
Reg. No./Substance:
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9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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