Document Detail


Isolation and primary structure of glucagon from the endocrine pancreas of Thunnus obesus.
MedLine Citation:
PMID:  1916209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glucagon has been isolated from the endocrine pancreas of a tunid, Thunnus obesus. The primary structure of the glucagon molecule was established as H S E G T F S N D Y S K Y L E T R R A Q D F V Q W L K N S. The sequence is identical to those of sculpin and flounder glucagon and glucagon II from anglerfish. It also shows high homology to the mammalian hormone (76%). The mass determined by fast-atom bombardment (3508) was consistent with the proposed structure. Immunological properties of the tuna glucagon were analyzed by radioimmunoassay, showing a high degree of cross-reactivity with the 30K antibody.
Authors:
I Navarro; J Gutiérrez; J Caixach; J Rivera; J Planas
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  83     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-11-15     Completed Date:  1991-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Affiliation:
Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Chromatography, Gel
Chromatography, High Pressure Liquid
Fishes / physiology
Glucagon / chemistry*,  isolation & purification
Humans
Islets of Langerhans / physiology*
Molecular Sequence Data
Radioimmunoassay
Sequence Homology, Nucleic Acid
Tuna / physiology*
Chemical
Reg. No./Substance:
9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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