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Isolation and preliminary biochemical characterization of the gonococcal H.8 antigen.
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MedLine Citation:
PMID:  3097238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have presented a method for the extraction and isolation of the gonococcal H.8 antigen. There was no evidence of contamination by other gonococcal proteins, phospholipids, or LPS. The purified H.8 antigen was subjected to preliminary analysis and appeared to be a proteolipid consisting of both protein and lipid components. The amino acid composition was unusual; the peptide portion of the antigen was an alanine and proline-rich molecule that lacked aromatic and sulfur-containing amino acids. The overall amino acid composition is hydrophobic. A lipid constituent was also identified; it was made up of at least two lipid components, which were unique to the H.8 molecule. The chemical nature of the association of the protein and lipid is presently unknown, but it is clearly a tenacious one.
Authors:
W Strittmatter; P J Hitchcock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  164     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-01-08     Completed Date:  1987-01-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2038-48     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis
Antigens, Bacterial / immunology,  isolation & purification*
Antigens, Surface / immunology,  isolation & purification
Chromatography, Gas
Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Lipids / analysis
Neisseria gonorrhoeae / immunology*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Antigens, Bacterial; 0/Antigens, Surface; 0/Lipids
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 12 Year: 1986
Volume: 164 Issue: 6
First Page: 2038 Last Page: 2048
ID: 2188499
Publisher Id: 87059653
PubMed Id: 3097238

Isolation and preliminary biochemical characterization of the gonococcal H.8 antigen


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