Document Detail

Isolation and potential existence of side population cells in adult human kidney.
MedLine Citation:
PMID:  18304230     Owner:  NLM     Status:  MEDLINE    
The existence of adult stem-like cells such as side population (SP) cells is reported in various kinds of animal tissues, and we recently reported that mice kidney SP cells differentiate into multilineage. However, there has thus far been no report about human kidney SP cells. In the present study, we examined the existence of SP cells in human kidney tissue by using Hoechst 33342 staining and fluorescence-activated cell sorting analysis. We used porcine kidney tissue to optimize the analysis conditions for human tissue, and found that the SP population in human kidney was 1.3%. The existence of SP cells in human kidney suggests that the cells could be good targets for clinical renal regenerative medicine.
Toshihiko Inowa; Keiichi Hishikawa; Takumi Takeuchi; Tadaichi Kitamura; Toshiro Fujita
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  15     ISSN:  1442-2042     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  272-4     Citation Subset:  IM    
Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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MeSH Terms
Cell Separation*
Flow Cytometry*
Kidney / cytology*
Middle Aged
Stem Cells*
Comment In:
Int J Urol. 2008 Mar;15(3):274-5   [PMID:  18304231 ]

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