Document Detail


Isolation of a novel mildly repetitive DNA sequence that is predominantly located at the terminus of the short arm of chromosome 4 near the Huntington disease gene.
MedLine Citation:
PMID:  2575587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel mildly repetitive DNA sequence that is reiterated approximately 20 times in the human genome has been isolated and characterized. Most of the repeat units are localized very near the terminus of the short arm of chromosome 4 (4p) in the region known to contain the Huntington disease (HD) gene. A cloned probe that detects the repeated sequence reveals a restriction fragment length polymorphism that is close to and/or distal to the most distal genetic locus on 4p. This probe, therefore, provides a new genetic marker very close to and possibly flanking the HD gene. In addition, this probe should prove very useful for detailed physical mapping of the most distal region of 4p around the HD gene. The few (two or three) copies of this repeat not located near the terminus of 4p are located near the ends of two other chromosomes, 14 and 21.
Authors:
M R Altherr; B Smith; M E MacDonald; L Hall; J J Wasmuth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  5     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-09     Completed Date:  1990-03-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  581-8     Citation Subset:  IM    
Affiliation:
Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Southern
Chromosome Mapping
Chromosomes, Human, Pair 4*
Cricetinae
DNA / genetics,  isolation & purification*
Genetic Markers
Haplotypes
Humans
Huntington Disease / genetics*
Hybrid Cells
Immunoblotting
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid*
Grant Support
ID/Acronym/Agency:
NS25631-02/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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