Document Detail


Isolation of a new tremorgenic indoloditerpene, 1'-O-acetylpaxilline, from Emericella striata and distribution of paxilline in Emericella spp.
MedLine Citation:
PMID:  2630106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of a tremorgenic mycotoxin, paxilline (1), was investigated in 19 species belonging to the genus Emericella. It was found that Emericella desertorum, E. foveolata, and E. striata produced paxilline (1). A new type of indoloditerpene, emindole DA (4), was also found in E. quadrilineata. A new tremorgenic indoloditerpene, 1'-O-acetylpaxilline (3), was isolated from the mycelium of E. striata. Its structure was established on the basis of spectroscopic investigations.
Authors:
K Nozawa; Y Horie; S Udagawa; K Kawai; M Yamazaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  37     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1989 May 
Date Detail:
Created Date:  1990-05-02     Completed Date:  1990-05-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1387-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Animals
Ascomycota / analysis,  metabolism*
Chemical Phenomena
Chemistry
Diterpenes / analysis,  isolation & purification*,  pharmacology
Indoles / analysis,  isolation & purification*,  metabolism*,  pharmacology
Mice
Tremor / chemically induced*
Chemical
Reg. No./Substance:
0/Diterpenes; 0/Indoles; 121998-08-1/1'-O-acetylpaxilline; 57186-25-1/paxilline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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