Document Detail


Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility.
MedLine Citation:
PMID:  16254824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A bioassay-guided separation of a methanolic extract obtained from the roots of Boerhaavia diffusa L. (Nyctaginaceae) allowed us to isolate five compounds belonging to the class of rotenoids: the known boeravinone D ( 1), boeravinone E ( 2), compound 5 and two novel compounds that we have named boeravinone G ( 3) and boeravinone H ( 4). The structures of the new molecules have been determined on the basis of their HR-EI-MS, (1)H- and (13)C-NMR and 2D-NMR (HMQC, HMBC) data. All the isolated rotenoids have been evaluated for their effect on intestinal motility in vitro. Three of them (boeravinone G, boeravinone E and compound 5) exhibited spasmolytic activity. Preliminary structure-activity relationships have been established highlighting the effect of substitutions on rings B and D.
Authors:
Francesca Borrelli; Natasa Milic; Valeria Ascione; Raffaele Capasso; Angelo A Izzo; Francesco Capasso; Francesca Petrucci; Roberta Valente; Ernesto Fattorusso; Orazio Taglialatela-Scafati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  71     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2005-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  928-32     Citation Subset:  IM    
Affiliation:
Dipartimento di Farmacologia Sperimentale, Università di Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy. franborr@unina.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Gastrointestinal Motility / drug effects*
Guinea Pigs
Male
Nyctaginaceae*
Parasympatholytics / administration & dosage,  pharmacology*,  therapeutic use
Phytotherapy*
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Plant Roots
Chemical
Reg. No./Substance:
0/Parasympatholytics; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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