Document Detail


Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia.
MedLine Citation:
PMID:  22803667     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new cinnamic acid derivative was isolated from the whole plant of Viola betonicifolia as off white needle. On the basis of various modern spectroscopic techniques including HREI-MS and 1D and 2D NMR, its structure was elucidated as 2,4-dihydroxy, 5-methoxy-cinnamic acid. It showed marked inhibition against DPPH (diphenyl-2-picryl hydrazyl) free radicals with IC(50) = 124 ± 5.76 µM. The antioxidant property of the compound was compared with α-tocopherole and vitamin C having IC(50) values 96 ± 0.46 and 90 ± 0.56 µM, respectively. In case of antiglycation assay, the compound exhibited moderate activity (IC(50) = 355 ± 7.56 µM) similar to standard compound, rutin (IC(50) = 294 ± 0.56 µM). However, it was non-toxic to PC-3 cell line. It is concluded that 2,4-dihydroxy, 5-methoxy-cinnamic acid has antiglycation potential which was further augmented by its antioxidant activity and thus offered an ideal natural therapeutic option for the effective management of diabetes.
Authors:
Naveed Muhammad; Muhammad Saeed; Achyut Adhikari; Khalid Muhammad Khan; Haroon Khan
Related Documents :
16661087 - Metabolism of l-tyrosine to 4-hydroxybenzaldehyde and 3-bromo-4-hydroxybenzaldehyde by ...
12486227 - Differential lipid biosynthesis underlies a tradeoff between reproduction and flight ca...
2879007 - The components of melissa officinalis l. that influence protein biosynthesis in-vitro.
3996087 - In vitro synergistic activity of some chinolinic compounds combined with beta-lactam an...
16018697 - Stepwise unidirectional synthesis of oligo phenylene vinylenes with a series of monomer...
19298007 - Analysis of fatty acids in early mid-life in fertile women: implications for reproducti...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-18
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  -     ISSN:  1475-6374     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmacy, University of Peshawar , Peshawar , Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphat...
Next Document:  Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studie...