Document Detail

Isolation of multidrug-resistant Salmonella typhimurium DT104 from swine in Korea.
MedLine Citation:
PMID:  18176546     Owner:  NLM     Status:  MEDLINE    
We report the isolation of Salmonella enterica serotype Typhimurium phage type DT104 (CCARM 8104) from swine in Korea. The CCARM 8104 isolate was resistant to nalidixic acid and showed reduced susceptibility to quinolones. The CCARM 8104 isolate had a missense mutation, Asp87Asn, in the quinolone resistance-determining region in gyrA and produced PSE-1. The CCARM 8104 isolate carried two different class 1 integrons, and the PSE-1 beta-lactamase gene was inserted into a 1,200 bp class 1 integron. The presence of DT104 with pse-1 in an integron located in a plasmid and reduced susceptibility to quinolone in swine pose a significant threat of possible horizontal spread between swine and humans.
Ki Eun Lee; Yeonhee Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of microbiology (Seoul, Korea)     Volume:  45     ISSN:  1225-8873     ISO Abbreviation:  J. Microbiol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-07     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9703165     Medline TA:  J Microbiol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  590-2     Citation Subset:  IM    
Culture Collection of Antimicrobial Resistant Microbes, Department of Biology, Seoul, Republic of Korea.
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MeSH Terms
Drug Resistance, Multiple, Bacterial / genetics*
Integrons / genetics
Intestines / microbiology
Nalidixic Acid / pharmacology
Quinolones / pharmacology
Salmonella Infections / microbiology
Salmonella typhimurium / drug effects,  genetics*,  isolation & purification*
Swine Diseases / microbiology
beta-Lactamases / genetics
Reg. No./Substance:
0/Quinolones; 389-08-2/Nalidixic Acid; EC 3.5.2.-/beta-lactamase PSE-1; EC

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