Document Detail


Isolation of a major metabolite (i-OHAP) of aprindine and its identification as N-[3-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol.
MedLine Citation:
PMID:  9635514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
i-OHAP, a major metabolite of aprindine (AP), was isolated by TLC from rat feces and identified as N-13-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol, based on 1H-NMR, the H-H correlation spectroscopy (COSY) spectrum, MS and LC-MS. Its structure was also confirmed by comparison with the synthesized compound. The hydroxy group of i-OHAP was located at the 5-position of the indan ring. AP is a prochiral compound, and the metabolism of AP to i-OHAP was stereoselective. The ratio of (+)/(-)-i-OHAP in rat feces and in human urine was about 5 and 15, respectively.
Authors:
M Shimizu; K Takatori; M Kajiwara; H Ogata
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  21     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-24     Completed Date:  1998-08-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  530-4     Citation Subset:  IM    
Affiliation:
Department of Biopharmaceutics, Meiji College of Pharmacy, Tanashi, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Anti-Arrhythmia Agents / pharmacokinetics*
Aprindine / analogs & derivatives*,  metabolism,  pharmacokinetics*,  urine
Biotransformation
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Feces / chemistry
Female
Humans
Magnetic Resonance Spectroscopy
Male
Rats
Rats, Wistar
Stereoisomerism
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/N-(3-(N,N-diethylamino)propyl)-N-phenyl-2-aminoindan-5-ol; 37640-71-4/Aprindine

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