| Isolation and identification of a new metabolite of naltrexone in human blood and urine. | |
| | |
MedLine Citation:
|
PMID: 1188187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A new metabolite of naltrexone was isolated from urine and erythrocytes of patients taking 100 mg naltrexone daily. Its tentative structure of 2-hydroxy-3-methoxy naltrexol was derived by analysis of the purified compound using gas chromatography combined with mass spectrometry, high resolution mass spectrometry and infrared spectrometry. Long bioavailability of the new metabolite is indicated by its slower excretion rate into the urine than naltrexone and beta-naltrexol. The rather high concentration of the new metabolite in the erythrocytes and its solubility in non-polar solvents like benzene demonstrate the ability of this compound to penetrate membranes. These features of the new metabolite suggest that it may contribute to naltrexone's long time course of action. |
| | |
Authors:
|
K Verebely; M A Chedekel; S J Mule; D Rosenthal |
Related Documents
:
|
15384147 - Identification of some new clemastine metabolites in dog, horse, and human urine with l... 761967 - Metabolic fate of aromatic hydrocarbons in aquatic organisms: analysis of metabolites b... 19083477 - Aspalathin, a flavonoid in aspalathus linearis (rooibos), is absorbed by pig intestine ... 14664837 - Quantitative determination of de-conjugated chrysene metabolites in fish bile by hplc-f... 15384147 - Identification of some new clemastine metabolites in dog, horse, and human urine with l... 17574937 - Measurement of ribavirin and evaluation of its stability in human plasma by high-perfor... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Research communications in chemical pathology and pharmacology Volume: 12 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1975 Sep |
Date Detail:
|
Created Date: 1976-01-26 Completed Date: 1976-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 67-84 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biological Availability Chromatography, Gas Chromatography, Thin Layer Erythrocytes / analysis Humans Hydroxylation Mass Spectrometry Naloxone / analogs & derivatives* Naltrexone / blood, metabolism*, urine Time Factors |
| Chemical | |
Reg. No./Substance:
|
16590-41-3/Naltrexone; 465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolism of glutethimide in the human.
Next Document: Resuscitation of patients with ischaemic heart disease before admission to hospital.