| Isolation and identification of 2-oxo-5-guanidinovaleric acid in urine of patients with hyperargininaemia by chromatography and gas chromatography/mass spectrometry. | |
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MedLine Citation:
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PMID: 7217896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An unknown guanidino-positive peak has been identified in urines of three sisters affected with hyperargininaemia. Identification was made on the basis of its similarity with the liquid and thin-layer chromatographic characteristics of enzymatically synthesized 2-oxo-5-guanidinovaleric acid. Identification was also made by combined gas chromatography-mass spectrometry of the unknown compound peak. The synthesis of enzymatically formed 2-oxo-5-guanidinovaleric acid was controlled by nuclear magnetic resonance and combined gas chromatography-mass spectrometry. |
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Authors:
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B Marescau; J Pintens; A Lowenthal; E Esmans; Y Luyten; G Lemière; R Dommisse; F Alderweireldt; H G Terheggen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie Volume: 19 ISSN: 0340-076X ISO Abbreviation: J. Clin. Chem. Clin. Biochem. Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-06-13 Completed Date: 1981-06-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7701860 Medline TA: J Clin Chem Clin Biochem Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 61-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Metabolism, Inborn Errors
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urine* Arginine / blood* Chemical Phenomena Chemistry Chromatography, Liquid Female Gas Chromatography-Mass Spectrometry Guanidines / urine* Humans Keto Acids / urine* Magnetic Resonance Spectroscopy |
| Chemical | |
Reg. No./Substance:
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0/Guanidines; 0/Keto Acids; 3715-10-4/alpha-keto-delta-guanidinovaleric acid; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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