| Isolation of human skin-derived lymph: flow and output of cells following sodium lauryl sulphate-induced contact dermatitis. | |
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MedLine Citation:
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PMID: 1503494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By means of microsurgery a peripheral subcutaneous lymph vessel draining a defined skin area was isolated and cannulated on the lower leg of six healthy volunteers. Lymph was collected over a period of 8 days. During the first 2 days baseline values for lymph flow and output of cells were established. A contact dermatitis was then induced in the drained skin area by the application of 10% sodium lauryl sulphate. All six probands developed a mild to moderate irritant contact dermatitis. Lymph flow as well as output of cells increased with the intensity of the skin reaction. Subsequent local treatment with clobetasol propionate decreased the cell output, but the lymph flow increased further. Neither lymph flow nor output of cells returned to the initial baseline values at the end of the study, when the clinical signs of contact dermatitis had completely disappeared. During the experiment significant individual variations were found, with means ranging from 0.10 to 0.48 ml/h for lymph flow and from 8700 to 174000/h for cells, which probably depended mainly on the different topographies and calibres of the cannulated lymph vessels. |
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Authors:
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C U Brand; T Hunziker; L R Braathen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of dermatological research Volume: 284 ISSN: 0340-3696 ISO Abbreviation: Arch. Dermatol. Res. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-09-15 Completed Date: 1992-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000462 Medline TA: Arch Dermatol Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 123-6 Citation Subset: IM |
Affiliation:
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Dermatological Clinic, Inselspital, University of Berne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Count Dermatitis, Contact / physiopathology* Female Humans Lymph / physiology* Male Skin / drug effects Sodium Dodecyl Sulfate / pharmacology |
| Chemical | |
Reg. No./Substance:
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151-21-3/Sodium Dodecyl Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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