| Isolation and expression of the Drosophila drosulfakinin neural peptide gene product, DSK-I. | |
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MedLine Citation:
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PMID: 19912877 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The Drosophila drosulfakinin (dsk) gene encodes the cholecystokinin homologues drosulfakinin-I (DSK-I) and drosulfakinin-II (DSK-II). The naturally occurring DSKI peptide was isolated from an extract of adult flies and its sequence determined by automated Edman degradation and sequence-specific radioimmunoassay. The dsk cDNA is expressed during the larval, pupal, and adult stages of development and is an abundant adult head transcript. Sequence-specific DSK antibodies localized DSK expression in the Drosophila larval central nervous system to medial neurosecretory cells and projections that extend from the neurons anteriorly into the brain and posteriorly down the ventral ganglion. The availability of the dsk transcript, sequence-specific DSK antibodies and the application of molecular genetics provide the opportunity to elucidate the role(s) of Drosophila CCK homologues in brain structure and function. |
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Authors:
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R Nichols |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: 3 ISSN: 1044-7431 ISO Abbreviation: Mol. Cell. Neurosci. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 2009-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 342-7 Citation Subset: - |
Affiliation:
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Departments of Biological Chemistry and Biology, University of Michigan, Ann Arbor, Michigan 48109-1048, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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