Document Detail

Isolation and expansion of resident cardiac progenitor cells.
MedLine Citation:
PMID:  17187455     Owner:  NLM     Status:  MEDLINE    
After myocardial infarction, loss of viable cardiomyocytes severely impairs cardiac function. Recently, stem cell transplantation has been put forward as a promising approach to repair the damaged heart. Although several clinical trials have already been performed, the dominant beneficial effects are probably due to neoangiogenesis and arteriogenesis. However, replacement of cardiomyocytes is vital to improve cardiac function in the long term. Stem cells and progenitor cells, with the capacity to differentiate into cardiomyocytes, have been described in both embryonic and adult tissues. Upon stimulation, cardiac progenitor cells proliferate and differentiate into cardiomyocytes, vascular smooth muscle cells, and endothelial cells. Currently however, high proliferation rates and differentiation of cardiac progenitor cells beyond the fetal stage have not yet been achieved. Full differentiation into adult cardiomyocytes in vitro and in vivo might be important for efficient integration with the host environment and therefore more research is needed to study factors that influence proliferation and differentiation. Here we will discuss the isolation of cardiac progenitor cells, their potential to differentiate into various cell types needed for cardiac repair, the possible mechanisms behind these events, and how these cells may be implemented in future clinical settings.
Patrick van Vliet; Joost P G Sluijter; Pieter A Doevendans; Marie-José Goumans
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  5     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-43     Citation Subset:  IM    
The Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.
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MeSH Terms
Antigens, CD31 / metabolism
Antigens, Ly / metabolism
Cell Differentiation
Cells, Cultured
Endothelial Cells / metabolism
Heart / embryology*
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cells / metabolism
Membrane Proteins / metabolism
Models, Animal
Myocardial Infarction / therapy
Myocardium / cytology
Myocytes, Cardiac / cytology*,  physiology*
Stem Cell Transplantation
Stem Cells / cytology*,  physiology*
Transcription, Genetic / physiology
Reg. No./Substance:
0/Antigens, CD31; 0/Antigens, Ly; 0/Ly6a protein, mouse; 0/Membrane Proteins

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