Document Detail


Isolation and cytotoxic properties of a novel glycoconjugate from corms of saffron plant (Crocus sativus L.).
MedLine Citation:
PMID:  9878746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel glycoconjugate isolated from saffron corm extracts shows remarkable cytotoxic activity on cultured human cancer cells (HeLa). Its polysaccharide part represents 94.5% of the molecule, and is dominated by a 36.4% of rhamnose. The protein backbone is composed mainly of aspartic acid/asparagine, alanine, glutamic acid/glutamine, glycine and serine. HeLa cells exposed to this glycoconjugate showed swelling and local plasma membrane evaginations, suggesting that cytotoxicity is mediated by extracellular fluid uptake.
Authors:
J Escribano; I Ríos; J A Fernández
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1426     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
Affiliation:
Sección de Biotecnología, Instituto de Desarrollo Regional, Universidad de Castilla-La Mancha, Campus Universitario s/n, E-02071, Albacete, Spain.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis
Antineoplastic Agents / isolation & purification*,  pharmacology
Hela Cells / drug effects,  pathology
Humans
Liliaceae / chemistry*
Plant Proteins / isolation & purification*,  pharmacology
Proteoglycans / isolation & purification*
Rhamnose / analysis
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Antineoplastic Agents; 0/Plant Proteins; 0/Proteoglycans; 10485-94-6/Rhamnose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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