| Isolation of copper-tolerant mutants of sake yeast with defective peptide uptake. | |
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MedLine Citation:
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PMID: 16310738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mutants of Saccharomyces cerevisiae that have a decreased peptide uptake ability were isolated from sake yeast. A copper medium containing copper sulfate, histidylleucine and sodium lactate as a carbon source was used for the isolation. One mutant showed a decreased peptide uptake ability due to PTR2 transcriptional repression, but for other mutants, the decrease was not due to the transcriptional repression. The peptide concentration in sake brewed with these mutants increased to about 1.5-fold that of sake brewed with the parental strain. The angiotensin I-converting enzyme (ACE) inhibitory activity of sake brewed with the mutant was about 3.6-fold that of sake brewed with the parental strain. |
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Authors:
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Tasuku Yamada; Keiji Furukawa; Shodo Hara; Haruhiko Mizoguchi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bioscience and bioengineering Volume: 100 ISSN: 1389-1723 ISO Abbreviation: J. Biosci. Bioeng. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2005-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888800 Medline TA: J Biosci Bioeng Country: Japan |
Other Details:
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Languages: eng Pagination: 460-5 Citation Subset: IM |
Affiliation:
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General Research Laboratory of Kiku-Masamune Sake Brewing Co., Ltd., 1-8-6 Uozaki-nishimachi, Higashinada-ku, Kobe 658-0026, Japan. ta-yamada@kikumasamune.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholic Beverages*
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microbiology Angiotensin-Converting Enzyme Inhibitors / pharmacology Base Sequence Copper / metabolism, pharmacology* Drug Resistance / genetics Fermentation Homeodomain Proteins / genetics Membrane Transport Proteins / genetics Molecular Sequence Data Mutation Peptides / metabolism* Peptidyl-Dipeptidase A / drug effects Protein Transport / genetics Saccharomyces cerevisiae / drug effects, genetics*, isolation & purification Saccharomyces cerevisiae Proteins / genetics Transcription Factors / genetics Ubiquitin-Protein Ligases / genetics |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/CUP9 protein, S cerevisiae; 0/Homeodomain Proteins; 0/Membrane Transport Proteins; 0/PTR2 protein, S cerevisiae; 0/Peptides; 0/Saccharomyces cerevisiae Proteins; 0/Transcription Factors; 7440-50-8/Copper; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 6.3.2.19/UBR1 protein, S cerevisiae; EC 6.3.2.19/Ubiquitin-Protein Ligases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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