Document Detail


Isolation and chromosomal assignment of 100 highly informative human simple sequence repeat polymorphisms.
MedLine Citation:
PMID:  1639389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One hundred highly informative simple sequence repeat (SSR) polymorphisms have been isolated and mapped to specific human chromosomes by somatic cell hybrid analysis. These markers include 97 (CA)n, 2 (AGAT)n, and a single (AACT)n repeat. All the SSRs have heterozygosities greater than 0.50 and can be amplified using identical PCR conditions. At least one SSR was detected on every chromosome, except for chromosomes 22 and Y. The frequency of (CA)n repeats on each chromosome was proportional to the relative chromosomal length, except for chromosome 15, on which a substantial excess of markers was identified.
Authors:
T J Hudson; M Engelstein; M K Lee; E C Ho; M J Rubenfield; C P Adams; D E Housman; N C Dracopoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  13     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-28     Completed Date:  1992-08-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  622-9     Citation Subset:  IM    
Affiliation:
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M87670;  M87671;  M87672;  M87673;  M87674;  M87675;  M87676;  M87677;  M87678;  M87679
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Chromosome Mapping
DNA / genetics
Genetic Markers
Heterozygote
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid*
Grant Support
ID/Acronym/Agency:
P50-HG00098/HG/NHGRI NIH HHS; R01-HG00395/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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