| Isolation and chromosomal assignment of 100 highly informative human simple sequence repeat polymorphisms. | |
MedLine Citation:
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PMID: 1639389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred highly informative simple sequence repeat (SSR) polymorphisms have been isolated and mapped to specific human chromosomes by somatic cell hybrid analysis. These markers include 97 (CA)n, 2 (AGAT)n, and a single (AACT)n repeat. All the SSRs have heterozygosities greater than 0.50 and can be amplified using identical PCR conditions. At least one SSR was detected on every chromosome, except for chromosomes 22 and Y. The frequency of (CA)n repeats on each chromosome was proportional to the relative chromosomal length, except for chromosome 15, on which a substantial excess of markers was identified. |
Authors:
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T J Hudson; M Engelstein; M K Lee; E C Ho; M J Rubenfield; C P Adams; D E Housman; N C Dracopoli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Genomics Volume: 13 ISSN: 0888-7543 ISO Abbreviation: Genomics Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-08-28 Completed Date: 1992-08-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8800135 Medline TA: Genomics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 622-9 Citation Subset: IM |
Affiliation:
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Department of Biology, Massachusetts Institute of Technology, Cambridge 02139. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/M87670; M87671; M87672; M87673; M87674; M87675; M87676; M87677; M87678; M87679 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Chromosome Mapping DNA / genetics Genetic Markers Heterozygote Humans Molecular Sequence Data Polymerase Chain Reaction Polymorphism, Genetic* Repetitive Sequences, Nucleic Acid* |
| Grant Support | |
ID/Acronym/Agency:
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P50-HG00098/HG/NHGRI NIH HHS; R01-HG00395/HG/NHGRI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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