Document Detail

Isolation and characterization of two verrucarins from Myrothecium roridum.
MedLine Citation:
PMID:  16869484     Owner:  NLM     Status:  MEDLINE    
In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verrucarin X (2), a new compound. Both 1 and 2 exhibit moderate antifungal activity and pronounced cytotoxic activity, with IC50 values in the nanomolar (1) and micromolar (2) range. Both compounds preferentially inhibit in vivo protein biosynthesis.
Sylvia Schoettler; Marcelo Bascope; Olov Sterner; Timm Anke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  61     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-07-27     Completed Date:  2006-10-06     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Department of Biotechnology, University of Kaiserslautern, Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany.
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MeSH Terms
Cell Line, Tumor
Cell Survival / drug effects
Colonic Neoplasms
HL-60 Cells
Jurkat Cells
Macrolides / chemistry*,  isolation & purification*,  pharmacology
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Protein Synthesis Inhibitors / chemistry,  isolation & purification*,  pharmacology
Trichothecenes / chemistry,  isolation & purification*,  pharmacology
Reg. No./Substance:
0/16-hydroxyverrucarin A; 0/Macrolides; 0/Protein Synthesis Inhibitors; 0/Trichothecenes; 0/verrucarin X; 3148-09-2/muconomycin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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