Document Detail


Isolation and characterization of three novel polyether antibiotics and three novel actinomycins as cometabolites of the same Streptomyces sp. X-14873, ATCC 31679.
MedLine Citation:
PMID:  2434456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Streptomyces sp. X-14873 (ATCC 31679) has been found to produce a number of secondary metabolites. Three have been identified as the novel actinomycins, X-14873B, C and D, each of which contains both proline and 3-hydroxy-5-methylproline. Potentially, the most important microbial product from this fermentation is the novel polyether antibiotic X-14873A which differs from lysocellin only in the substituents at carbons C-4 and C-5 in the tetrahydropyranyl ring. The methyl group and proton in lysocellin are replaced by an ethyl and hydroxyl group, respectively in X-14873A. In addition, two other novel polyethers, X-14873H and G, were isolated and shown to differ from 1 in lacking a carboxyl group and in the case of 3, possessing an ether bridge across the terminal tetrahydrofuranyl ring system.
Authors:
J W Westley; C M Liu; J F Blount; L Todaro; L H Sello; N Troupe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  39     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-04-10     Completed Date:  1987-04-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1704-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / isolation & purification*
Chemical Phenomena
Chemistry
Crystallization
Dactinomycin / analogs & derivatives*,  isolation & purification*
Mice
Molecular Conformation
Streptomyces / metabolism*
Thallium
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 50-76-0/Dactinomycin; 50813-20-2/actinomycin X; 7440-28-0/Thallium
Comments/Corrections
Erratum In:
J Antibiot (Tokyo) 1987 Jun;40(6):following 916

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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