Document Detail

Isolation and characterization of a repeated sequence (RPS1) of Candida albicans.
MedLine Citation:
PMID:  1402790     Owner:  NLM     Status:  MEDLINE    
A repeated sequence, named RPS1, approximately 2 kb in size, is found mainly in chromosome 6, the second most variable chromosome among the eight chromosomes of Candida albicans. Most of the RPS1 units of chromosome 6 seem to be located within a single region of about 100 kb in strain FC18. In both strains FC18 and NUM812, a part of RPS1 is apparently tandemly repeated. A unit of RPS1 has been cloned and sequenced. It consists of 2114 bp and has a GC content of 40 mol%. The repeat unit contains smaller repeats of about 80-170 bp which are called REP1, REP2, REP3, REP4 and REP5; REP2 is duplicated. The small repeats are classified into two groups by their homology. One comprises REP1, REP2 and REP5, and the other REP3 and REP4. They are termed the REP1 and REP3 families, respectively. The two families both contain a common 29 bp sequence, called COM29. The dispersed repetitive sequence RPS1 may be involved in chromosomal rearrangements and may in part explain chromosome polymorphism in C. albicans. The origin of RPS1 was not determined.
S Iwaguchi; M Homma; H Chibana; K Tanaka
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of general microbiology     Volume:  138     ISSN:  0022-1287     ISO Abbreviation:  J. Gen. Microbiol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-25     Completed Date:  1992-11-25     Revised Date:  2005-01-21    
Medline Journal Info:
Nlm Unique ID:  0375371     Medline TA:  J Gen Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1893-900     Citation Subset:  IM    
Laboratory of Medical Mycology, Nagoya University School of Medicine, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M85087;  M85088;  M85089;  M85090;  M85091;  M85092;  M85093;  M85094;  M87288;  M88253
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MeSH Terms
Base Sequence
Candida albicans / genetics*
Chromosome Mapping
Chromosomes, Fungal
Cloning, Molecular
DNA, Fungal / genetics*
Molecular Sequence Data
Nucleic Acid Hybridization
Repetitive Sequences, Nucleic Acid / genetics*
Reg. No./Substance:
0/DNA, Fungal

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