Document Detail


Isolation and characterization of drug delivering potential of type-I collagen from eel fish Evenchelys macrura.
MedLine Citation:
PMID:  22538728     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Acid soluble collagen (ASC) and pepsin-soluble collagen (PSC) from the outer skin waste of marine eel fish (Evenchelys macrura) were isolated and characterized. The prepared collagen was used to test its effective drug delivering potential in vitro condition. Present results were confirmed as collagen by different physico-chemical techniques like SDS-PAGE, HPLC, FTIR and SEM. Further amino acid analysis corroborates isolation of type I collagen. Both ASC and PSC comprising two different α-chains (α 1 and α 2) were characterized as type I and contained imino acid of 190-200 residues, respectively. The denaturation temperatures (T(d)) of ASC and PSC were 38.5 and 35.0 °C, respectively, which is promising as an advantage for biomedical application due to closeness in T(d) to mammalian collagen. Furthermore, the gel and film forming capability of collagen samples containing implant standard antibiotic was proved to be a suitable drug delivering system.
Authors:
Anguchamy Veeruraj; Muthuvel Arumugam; Thangappan Ajithkumar; Thangavel Balasubramanian
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-27
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  -     ISSN:  1573-4838     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai Univeristy, Parangipettai, 608 502, TamilNadu, India, anguveeruraj@gmail.com.
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