| Isolation, characterization and biological activities of verotetrone from a mutant strain of Streptomyces aureofaciens. | |
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MedLine Citation:
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PMID: 6774935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new metabolite denoted as verotetrone was isolated from the mycelium of the mutant strain Streptomyces aureofaciens NMG-2. Interpretations of physical data concerning verotetrone and its triacetate and, the determination of its degradation product indicate that verotetrone belongs to pretetramide-type metabolites. Verotetrone exhibits neither antibacterial nor antifungal activity. In vitro it inhibits the synthesis of nucleic acids as well as proteins in Ehrlich ascites carcinoma cells. Both verotetrone and its triacetate interfere in vivo with the metabolism of tumour and lymphoid cells, exhibiting antitumour or immunosuppressive activity. This activity, which is more intense with verotetrone than with its triacetate, is detectable in a dose which is already toxic in some animals. |
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Authors:
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V Prikrylová; M Podojil; I Hilgert; J Fuska; J Vokoun; Z Vanĕk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Folia microbiologica Volume: 25 ISSN: 0015-5632 ISO Abbreviation: Folia Microbiol. (Praha) Publication Date: 1980 |
Date Detail:
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Created Date: 1980-12-16 Completed Date: 1980-12-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376757 Medline TA: Folia Microbiol (Praha) Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 289-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthracyclines* Antibiotics, Antineoplastic* Bacteria / drug effects Candida / drug effects Carcinoma, Ehrlich Tumor / metabolism Female Leukemia, Experimental / drug therapy, immunology Mice Mice, Inbred Strains Mutation Naphthacenes / analysis, isolation & purification, pharmacology Neoplasms, Experimental Nucleic Acids / biosynthesis Streptomyces aureofaciens / metabolism* Transplantation Immunology |
| Chemical | |
Reg. No./Substance:
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0/Anthracyclines; 0/Antibiotics, Antineoplastic; 0/Naphthacenes; 0/Nucleic Acids; 80702-87-0/verotetrone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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