Document Detail


Isolation, characterization and biological activities of verotetrone from a mutant strain of Streptomyces aureofaciens.
MedLine Citation:
PMID:  6774935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new metabolite denoted as verotetrone was isolated from the mycelium of the mutant strain Streptomyces aureofaciens NMG-2. Interpretations of physical data concerning verotetrone and its triacetate and, the determination of its degradation product indicate that verotetrone belongs to pretetramide-type metabolites. Verotetrone exhibits neither antibacterial nor antifungal activity. In vitro it inhibits the synthesis of nucleic acids as well as proteins in Ehrlich ascites carcinoma cells. Both verotetrone and its triacetate interfere in vivo with the metabolism of tumour and lymphoid cells, exhibiting antitumour or immunosuppressive activity. This activity, which is more intense with verotetrone than with its triacetate, is detectable in a dose which is already toxic in some animals.
Authors:
V Prikrylová; M Podojil; I Hilgert; J Fuska; J Vokoun; Z Vanĕk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia microbiologica     Volume:  25     ISSN:  0015-5632     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  1980  
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthracyclines*
Antibiotics, Antineoplastic*
Bacteria / drug effects
Candida / drug effects
Carcinoma, Ehrlich Tumor / metabolism
Female
Leukemia, Experimental / drug therapy,  immunology
Mice
Mice, Inbred Strains
Mutation
Naphthacenes / analysis,  isolation & purification,  pharmacology
Neoplasms, Experimental
Nucleic Acids / biosynthesis
Streptomyces aureofaciens / metabolism*
Transplantation Immunology
Chemical
Reg. No./Substance:
0/Anthracyclines; 0/Antibiotics, Antineoplastic; 0/Naphthacenes; 0/Nucleic Acids; 80702-87-0/verotetrone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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