Document Detail

Isolation and characterization of antibiotic NC0604, a new analogue of bleomycin.
MedLine Citation:
PMID:  19194033     Owner:  NLM     Status:  MEDLINE    
NC0604, a new analogue of bleomycin, was isolated from fermentation broth of Streptomyces verticillus var. pingyangensis n.var. The structure of NC0604 was elucidated by spectroscopic analyses. NC0604 had the same kernel structure as bleomycin, but a different terminal amine moiety determined as amidepropyl spermidine. NC0604 exhibited antibacterial activity against a wide range of bacterial species and showed cytotoxicity in vitro against human HepG(2), KB, MCF-7, HCT116, BGC-823 and MCF-7/DOX cells with IC(50) values of 1.18, 1.21, 1.41, 1.83, 2.02, 1.45 muM, respectively. The antitumor activity of NC0604 against these cells was 3~9 times higher than that of bleomycin; and the pulmonary toxicity of NC0604 was much lower than that of bleomycin.
Caixia Chen; Shuyi Si; Qiyang He; Hongzhang Xu; Min Lu; Yunying Xie; Yan Wang; Ruxian Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  61     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-02-05     Completed Date:  2009-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  747-51     Citation Subset:  IM    
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tian Tan Xi Li No 1, Beijing 100050, P.R. China.
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MeSH Terms
Anti-Bacterial Agents / chemistry*,  isolation & purification,  pharmacology*,  toxicity
Antineoplastic Agents / chemistry*,  isolation & purification,  pharmacology*,  toxicity
Bleomycin / analogs & derivatives*,  isolation & purification,  pharmacology,  toxicity
Cell Line, Tumor
Culture Media / chemistry*
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Inhibitory Concentration 50
Microbial Sensitivity Tests
Spectrum Analysis
Streptomyces / metabolism*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antineoplastic Agents; 0/Culture Media; 11056-06-7/Bleomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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