| Isolation and characterization of anti-diabetic component (bioactivity-guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part. | |
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MedLine Citation:
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PMID: 21771470 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To isolate and characterize antidiabetic component (bioactivity-guided fractionation) from hydro alcoholic extract of Ocimum sanctum (O. sanctum) aerial part. METHODS: Ten fractions (F1 - F10) were isolated from hydro alcoholic extract of O. sanctum aerial part by column chromatography. All the fractions F1 to F10 were screened for antidiabetic activity in alloxan induced diabetic rats by estimating serum glucose level and lipid parameters. The isolated bioactive component was elucidated on the basis of extensive spectroscopic (UV, IR, MS, (1)H and (13)C NMR) data analysis. RESULTS: The bioactive fraction (F5) was found to be potent antidiabetic by ameliorating glucose and lipid parameters (total cholesterol, triglycerides, low and high density lipoprotein cholesterol). The extensive spectroscopic data analysis reveals that, the isolated bioactive compound elucidated as tetracyclic triterpenoid [16-Hydroxy-4,4,10,13-tetramethyl-17-(4-methyl-pentyl)-hexadecahydro-cyclopenta[a]phenanthren-3-one]. CONCLUSIONS: Our present study concluded that, tetracyclic triterpenoid isolated from aerial part of O. sanctum has a great anti-diabetic potential. |
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Authors:
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Raju Patil; Ravindra Patil; Bharati Ahirwar; Dheeraj Ahirwar |
Publication Detail:
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Type: Journal Article Date: 2011-05-29 |
Journal Detail:
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Title: Asian Pacific journal of tropical medicine Volume: 4 ISSN: 1995-7645 ISO Abbreviation: Asian Pac J Trop Med Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-07-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101533720 Medline TA: Asian Pac J Trop Med Country: Singapore |
Other Details:
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Languages: eng Pagination: 278-82 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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CEC School of Pharmacy, Lal Khadan, Masturi Road, Bilaspur (C.G.), India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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