Document Detail

Isolation and characterization of the Rickettsia prowazekii recA gene.
MedLine Citation:
PMID:  8132476     Owner:  NLM     Status:  MEDLINE    
The recA gene has been isolated from Rickettsia prowazekii, an obligate intracellular bacterium. Comparison of the amino acid sequence of R. prowazekii RecA with that of Escherichia coli RecA revealed that 62% of the residues were identical. The highest identity was found with RecA of Legionella pneumophila, in which 69% of the residues were identical. Amino acid residues of E. coli RecA associated with functional activities are conserved in rickettsial RecA, and the R. prowazekii recA gene complements E. coli recA mutants for UV light and methyl methanesulfonate sensitivities as well as recombinational deficiencies. The characterized region upstream of rickettsial recA did not contain a sequence homologous to an E. coli LexA binding site (SOS box), suggesting differences in the regulation of the R. prowazekii recA gene.
S M Dunkin; D O Wood
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bacteriology     Volume:  176     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-21     Completed Date:  1994-04-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1777-81     Citation Subset:  IM    
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688.
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MeSH Terms
Amino Acid Sequence
Genes, Bacterial / genetics*
Molecular Sequence Data
Rec A Recombinases / chemistry*,  genetics*
Rickettsia prowazekii / genetics*
Sequence Homology, Amino Acid
Grant Support
Reg. No./Substance:
EC 2.7.7.-/Rec A Recombinases

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