Document Detail


Isolation and characterization of Gal E mutant Ty 21a of Salmonella typhi: a candidate strain for a live, oral typhoid vaccine.
MedLine Citation:
PMID:  1092768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A gal E mutant of Salmonella typhi was isolated; results obtained with Salmonella typhimurium and the mouse as a model for human typhoid fever indicated that this mutant has the potential for use as a live, oral typhoid vaccine. The mutant, Ty 21a, took up galactose from exogenous sources and accumulated sufficient quantities of galactose-1-phosphate and uridine diphosphate galactose to cause lysis of the cells, an event that resulted in the avirulence of the strain. Galactose was incorporated sufficiently into the cell wall of Ty 21a to allow the synthesis of smooth-type lipopolysaccharides, which are necessary for the proper immunogenicity. Cells of strain Ty 21a, when given intraperitoneally, protected mice against lethal challenge with strain Ty 2 of S. typhi.
Authors:
R Germanier; E Füer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  131     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-07-18     Completed Date:  1975-07-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteriological Techniques
Bacteriolysis / drug effects
Carbon Radioisotopes
Chromatography, Ion Exchange
Galactose / metabolism,  pharmacology
Immunization, Secondary
Liver / microbiology
Mice
Mutation*
Salmonella typhi / enzymology,  isolation & purification*
Spleen / microbiology
Typhoid-Paratyphoid Vaccines*
UDPglucose 4-Epimerase
UTP-Hexose-1-Phosphate Uridylyltransferase
Virulence
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Typhoid-Paratyphoid Vaccines; 26566-61-0/Galactose; EC 2.7.7.10/UTP-Hexose-1-Phosphate Uridylyltransferase; EC 5.1.3.2/UDPglucose 4-Epimerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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