Document Detail

Isolation and characterization of 19 dinucleotide repeat polymorphisms on chromosome 3p.
MedLine Citation:
PMID:  1301149     Owner:  NLM     Status:  MEDLINE    
We have screened cosmids on chromosome 3p for (dC-dA)n.(dG-dT)n dinucleotide-repeat sequences. Eighty-nine of 155 cosmids (58%) contained (dC-dA)n.(dG-dT(n repeats as determined by colony hybridization with a (dG-dT)10 oligonucleotide probe; 29 of these were subcloned and the sequences flanking the dinucleotide repeats were determined. Nineteen of the 24 loci examined for polymorphisms by PCR were found to be polymorphic with heterozygosities ranging from 3% to 86%. These dinucleotide repeat polymorphisms will be useful markers for high-resolution mapping of genes that have been localized to 3p, including tumour suppressor genes associated with several types of cancer and genes responsible for various hereditary disorders, such as von Hippel-Lindau disease.
M H Jones; K Yamakawa; Y Nakamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human molecular genetics     Volume:  1     ISSN:  0964-6906     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  1992 May 
Date Detail:
Created Date:  1993-05-28     Completed Date:  1993-05-28     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  131-3     Citation Subset:  IM    
Department of Biochemistry, Cancer Institute, Tokyo, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/D01080;  D01081;  D01082;  D01083;  D01084;  D10090;  D10091;  D10092;  D10093;  D10094;  D10095;  D10096;  D10097;  D10098;  D10099;  D10100;  D10101;  D10102;  D10103
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MeSH Terms
Base Sequence
Chromosomes, Human, Pair 3*
DNA, Single-Stranded
Hybrid Cells
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid*
Reg. No./Substance:
0/DNA, Single-Stranded; 0/Oligodeoxyribonucleotides

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