Document Detail


Isolation and characterization of 19 dinucleotide repeat polymorphisms on chromosome 3p.
MedLine Citation:
PMID:  1301149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have screened cosmids on chromosome 3p for (dC-dA)n.(dG-dT)n dinucleotide-repeat sequences. Eighty-nine of 155 cosmids (58%) contained (dC-dA)n.(dG-dT(n repeats as determined by colony hybridization with a (dG-dT)10 oligonucleotide probe; 29 of these were subcloned and the sequences flanking the dinucleotide repeats were determined. Nineteen of the 24 loci examined for polymorphisms by PCR were found to be polymorphic with heterozygosities ranging from 3% to 86%. These dinucleotide repeat polymorphisms will be useful markers for high-resolution mapping of genes that have been localized to 3p, including tumour suppressor genes associated with several types of cancer and genes responsible for various hereditary disorders, such as von Hippel-Lindau disease.
Authors:
M H Jones; K Yamakawa; Y Nakamura
Related Documents :
7759089 - Characterisation of three microsatellite polymorphisms (d21s1262, d21s1419 and d21s1421...
15180699 - Molecular analysis of gaa repeats and four linked bi-allelic markers in and around the ...
18192679 - Huntingtin-associated protein-1 is a modifier of the age-at-onset of huntington's disease.
7633439 - Molecular features of the cag repeats and clinical manifestation of machado-joseph dise...
8465889 - Alexithymia in victims of sexual assault: an effect of repeated traumatization?
17708569 - A south african mixed ancestry family with huntington disease-like 2: clinical and gene...
24500949 - Combining fish and model-based predictions to understand chromosome evolution in typhon...
10740919 - Localization of genes affecting species differences in male courtship song between dros...
7627929 - Characterization by chromosome painting of balanced and unbalanced x chromosome translo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human molecular genetics     Volume:  1     ISSN:  0964-6906     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  1992 May 
Date Detail:
Created Date:  1993-05-28     Completed Date:  1993-05-28     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  131-3     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Cancer Institute, Tokyo, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/D01080;  D01081;  D01082;  D01083;  D01084;  D10090;  D10091;  D10092;  D10093;  D10094;  D10095;  D10096;  D10097;  D10098;  D10099;  D10100;  D10101;  D10102;  D10103
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Chromosomes, Human, Pair 3*
Cosmids
DNA, Single-Stranded
Female
Heterozygote
Humans
Hybrid Cells
Male
Mice
Molecular Sequence Data
Oligodeoxyribonucleotides
Pedigree
Polymerase Chain Reaction
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid*
Chemical
Reg. No./Substance:
0/DNA, Single-Stranded; 0/Oligodeoxyribonucleotides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A male with two contiguous inactivation centers on a single X chromosome: study of X inactivation an...
Next Document:  An autosomal homologue of the choroideremia gene colocalizes with the Usher syndrome type II locus o...