| Isolation of analogues of okadaic acid from cultures of Prorocentrum lima. | |
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MedLine Citation:
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PMID: 1340349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A chloroform extract of cultured Prorocentrum lima was analyzed for carboxylic polyethers related to okadaic acid (OA). The extract was derivatized with 1-(bromoacetyl)pyrene to give the fluorescent pyrenacyl esters of OA and other carboxylic acids. The resulting mixture was subjected to preparative high performance liquid chromatography with fluorescence detection. Positive chemical ionization mass spectrometry indicated that four OA-related compounds were present, including two methylated analogues. The fragmentation pattern of at least one of these suggests it is not the previously reported 35-methylokadaic acid. |
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Authors:
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H R Granade; F A Bencsath; R W Dickey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin de la Société de pathologie exotique (1990) Volume: 85 ISSN: 0037-9085 ISO Abbreviation: Bull Soc Pathol Exot Publication Date: 1992 |
Date Detail:
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Created Date: 1993-12-17 Completed Date: 1993-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9212564 Medline TA: Bull Soc Pathol Exot Country: FRANCE |
Other Details:
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Languages: eng Pagination: 478-80 Citation Subset: IM |
Affiliation:
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US Food and Drug Administration, Division of Seafood Research, Dauphin Island, AL 36528. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid Dinoflagellida / chemistry* Ethers, Cyclic / isolation & purification* Mass Spectrometry Okadaic Acid Virgin Islands of the United States |
| Chemical | |
Reg. No./Substance:
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0/Ethers, Cyclic; 78111-17-8/Okadaic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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