Document Detail

Isolation of adenovirus type 11 from the brain of a neonate with pneumonia and encephalitis.
MedLine Citation:
PMID:  8335017     Owner:  NLM     Status:  MEDLINE    
We describe a fatal case of adenovirus pneumonia accompanied by encephalitis in a neonate who showed lethargy on the 6th day and died on the 12th day. Adenoviral particles as well as viral intranuclear inclusions were noted in pulmonary alveolar epithelium cells. Neuropathological examination revealed diffuse oedema, perivascular cuffing and gliosis in the white matter. Adenovirus type 11 was isolated from lung, hilar lymph node, and brain tissue. This is the first instance of adenovirus isolation from brain tissue in a newborn infant. The virological and neuropathological findings suggest the invasion of neural tissue by adenovirus and substantiate the significance of neurological symptoms observed in neonatal adenovirus infection.
T Osamura; R Mizuta; H Yoshioka; S Fushiki
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of pediatrics     Volume:  152     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-25     Completed Date:  1993-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  496-9     Citation Subset:  IM    
Department of Paediatrics, Kyoto Second Red Cross Hospital, Japan.
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MeSH Terms
Adenovirus Infections, Human / microbiology*
Adenoviruses, Human / classification,  isolation & purification*
Brain / microbiology*,  pathology
Encephalitis / microbiology*,  pathology
Infant, Newborn
Pneumonia, Viral / microbiology*

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