Document Detail


Isolation of Staphylococcus aureus and black-pigmented bacteroides indicate a high risk for the development of Ludwig's angina.
MedLine Citation:
PMID:  19836722     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to compare clinical, microbiological, enzymatic, and host immune response variables between subjects hospitalized with facial cellulitis, with Ludwig's angina (LA) and without Ludwig's angina (WOLA). STUDY DESIGN: Microbiological and enzymatic tests on pus, and hematological and immunological assessments on blood samples of 15 patients with LA and 42 patients with WOLA were performed. Laboratory findings of both groups were compared using the Student t test. Multiple logistic regression analysis was performed and significant differences identified by univariate analysis. RESULTS: Patients with LA demonstrated increased levels of white blood cell counts, urea, and CRP levels, and decreased levels of CIC compared with patients WOLA. However, only CRP and urea were found to be significantly raised in the LA group. A greater population of Staphylococcus aureus and black-pigmented bacteroides were isolated from patients with LA. CONCLUSION: Elevated levels of CRP and urea could indicate the severity of infection in patients with LA. This could be because of the highly virulent and fast-spreading organisms, S. aureus and black-pigmented bacteroides, which may be a factor indicative of LA.
Authors:
Mrudula Patel; Thoganthiren Perumal Chettiar; Ahmed A Wadee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  108     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  667-72     Citation Subset:  D; IM    
Affiliation:
Division of Oral Microbiology, Department of Clinical Microbiology, National Health Laboratory Services, Faculty of Health Sciences, University of the Witwatersrand, Gauteng, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bacteroides / isolation & purification
Bacteroides Infections / complications*
C-Reactive Protein / analysis
Cellulitis / complications,  microbiology
Colony Count, Microbial
Female
Focal Infection, Dental / blood,  complications*,  microbiology
Humans
Logistic Models
Ludwig's Angina / blood,  etiology*,  immunology,  microbiology*
Male
Middle Aged
Mouth Diseases / microbiology
Risk Factors
Staphylococcal Infections / complications*
Staphylococcus aureus / isolation & purification
Suppuration / enzymology,  microbiology
Urea / blood
Young Adult
Chemical
Reg. No./Substance:
57-13-6/Urea; 9007-41-4/C-Reactive Protein

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