Document Detail

Isolation and Neuroprotective Activities of Acylated Iridoids from Valeriana jatamansi.
MedLine Citation:
PMID:  22782884     Owner:  NLM     Status:  In-Data-Review    
Three new iridoids, jatairidoids A-C (1-3, resp.), have been isolated from the roots of Valeriana jatamansi (V. wallichii). Their structures were elucidated by spectroscopic methods (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR). Compounds 1 and 2 are C(3)-epimers. The three compounds were evaluated for their neuroprotective effects against MPP(+) -induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells. All the isolates exhibited moderate neuroprotective effects.
Jing Xu; Yuanqiang Guo; Chunfeng Xie; Da-Qing Jin; Jie Gao; Liping Gui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  9     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1382-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.
College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, P. R. China (phone/fax: +86-22-23502595).
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