Document Detail

Isolation and Identification of Flavobacterium columnare and Streptococcus iniae Antibacterial Compounds from the Terrestrial Plant Atraphaxis laetevirens.
MedLine Citation:
PMID:  23030835     Owner:  NLM     Status:  Publisher    
Columnaris disease, enteric septicemia of catfish, and streptococcosis are common bacterial diseases of certain freshwater fish and are caused by Flavobacterium columnare, Edwardsiella ictaluri, and Streptococcus iniae, respectively. During the process of evaluating several species of plants in order to isolate and identify compounds with toxicity against these bacteria, a promising extract from the aerial parts of the terrestrial plant Atraphaxis laetevirens (Ledeb.) Jaub. et Spach (Polygonaceae Juss.) was selected for bioassay-guided fractionation using a rapid microplate bioassay. The active dichloromethane extract underwent liquid-liquid partitioning, and active fractions were further separated by normal phase column chromatography and normal phase HPLC. Nepodin (3) and emodin (4) were isolated from two fractions with strong toxicities against S. iniae. A chloroform fraction was further separated by normal phase column chromatography to yield two active fractions against F. columnare, and these fractions contained chrysophanol (1), physcion (2), and 3. Compound 1 had strong activity and 3 had moderate activity against F. columnare while 2 and 4 were not toxic at the concentrations tested.
Hiroshi Nakano; Kevin K Schrader; Leonid K Mamonov; Tatyana S Kustova; Valentina K Mursaliyeva; Charles L Cantrell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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