Document Detail


Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense.
MedLine Citation:
PMID:  22161763     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new pentanorlanostane, ganosineniol A ( 1), eight new lanostane triterpenoids, ganosinoside A ( 2), ganoderic acid Jc ( 3), ganoderic acid Jd ( 4), ganodermatetraol ( 5), ganolucidic acid γa ( 6), ganolucidate F ( 7), ganoderiol J ( 8), and methyl lucidenate Ha ( 9), and a new sesquiterpenoid, ganosinensine ( 10), together with eleven known triterpenoids ( 11- 21), were isolated from the fruiting bodies of the fungus GANODERMA SINENSE. Chemical structures were determined based on spectroscopic evidence, including 1D, 2D NMR, and mass spectral data. Furthermore, all isolates were tested for cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression. Among them, ganoderic acid Jc ( 3) displayed selective inhibitory activity against HL-60 cells (IC (50) = 8.30 µM), and ganoderiol E ( 11) exhibited selective cytotoxic activity against MCF-7 cells (IC (50) = 6.35 µM). Meanwhile, compounds 5, 7, and ganolucidic acids B and C ( 19, 20) showed induction ability of hPXR-mediated CYP3A4 expression.
Authors:
Jie-Qing Liu; Cui-Fang Wang; Yan Li; Huai-Rong Luo; Ming-Hua Qiu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-12
Journal Detail:
Title:  Planta medica     Volume:  -     ISSN:  1439-0221     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P. R. China.
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