| Isolation of Apoptosis-Inducing Stilbenoids from Four Members of the Orchidaceae Family. | |
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MedLine Citation:
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PMID: 22002852 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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High-throughput natural product research produced a suite of anticancer hits among several species of the Orchidaceae family ( ONCIDIUM MICROCHILUM, O. ISTHMI, and MYRMECOPHILA HUMBOLDTII). A commercial ONCIDIUM sp. was also examined as a convenient source of additional material. Isolation and structure elucidation led to the identification of fifteen stilbenoids including a new phenanthraquinone and two new dihydrostilbenes. NMR data for structure elucidation and dereplication were acquired utilizing a Bruker BioSpin TCI 1.7-mm MicroCryoProbe or a 5-µL CapNMR capillary microcoil. Several compounds inhibited proliferation of NCI-H460 and M14 cancer cell lines. All compounds were also examined for their ability to induce apoptosis. Apoptosis induction was determined by measuring caspase 3/7 activation and LDH release in a NCI-H460 cell line. Based on these results, a portion of the extract from a commercially available ONCIDIUM sp. was chemically modified in an attempt to obtain additional phenanthraquinones. |
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Authors:
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Russell B Williams; Steven M Martin; Jin-Feng Hu; Eliane Garo; Stephanie M Rice; Vanessa L Norman; Julie A Lawrence; Grayson W Hough; Matt G Goering; Mark O'Neil-Johnson; Gary R Eldridge; Courtney M Starks |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-14 |
Journal Detail:
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Title: Planta medica Volume: - ISSN: 1439-0221 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., St. Louis, Missouri, USA. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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