Document Detail


Isolated trisomy 15: a clonal chromosome abnormality in bone marrow with doubtful hematologic significance.
MedLine Citation:
PMID:  18285273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We identified 18 patients with an isolated bone marrow clonal chromosomal abnormality, trisomy 15 (with or without -Y), who did not have any morphologic or clinical features of hematologic disease at initial examination. All but 1 patient was older than 65 years. Fourteen patients had underlying nonhematologic, chronic diseases. Four patients had histories of hematologic malignancies. Eleven of the patients also had a -Y. All but 1 case had a marrow cellularity of less than 50%. Extensive morphologic review of the specimens showed no features of myelodysplastic syndrome (MDS). Clinical follow-up was available for all patients and ranged from 1 month to 16.3 years (median, 4.0 years). No subsequent clinical or hematologic manifestations of MDS were identified in any of these patients. Clonal trisomy 15 in isolation or in combination with -Y is an uncommon cytogenetic finding that does not seem to be associated with definitive morphologic or clinical features of MDS or any other malignant process.
Authors:
Curtis A Hanson; David P Steensma; Janice M Hodnefield; Phuong L Nguyen; James D Hoyer; David S Viswanatha; Ying Zou; Ryan A Knudson; Daniel L Van Dyke; Rhett P Ketterling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  129     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  478-85     Citation Subset:  AIM; IM    
Affiliation:
Division of Hematopathology, Mayo Clinic College of Medicine, Rochester, MN 55955, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Bone Marrow Cells / cytology,  physiology*
Chromosome Deletion
Chromosomes, Human, Pair 15 / genetics*
Chromosomes, Human, Y / genetics
Female
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Trisomy / genetics*

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