Document Detail

Isolated tricuspid stenosis and heart failure: a focus on carcinoid heart disease.
MedLine Citation:
PMID:  14564150     Owner:  NLM     Status:  MEDLINE    
A rare clinical occurrence, heart failure in the setting of tricuspid stenosis should immediately trigger a search for underlying systemic carcinoid disease. Carcinoid tumor cells can secrete a variety of vasoactive substances that result in skin erythema, excretory diarrhea, bronchospasm, and hemodynamic instability, but these manifestations are noted only in a few patients. Right heart valvular disease is common since the vasoactive noxious substances pass through the right heart unaffected and undergo metabolism in the pulmonary circulation, thereby decreasing involvement of the left-sided valves. Localization of the carcinoid tumor followed by surgically directed valvular treatment is mandatory for relief of symptoms. In nonoperative candidates, cytotoxic chemotherapy or long-term symptomatic drug treatment with somatostatin is indicated.
Mallikarjun R Thatipelli; Patricia A Uber; Mandeep R Mehra
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  9     ISSN:  1527-5299     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-10-17     Completed Date:  2004-01-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  294-6     Citation Subset:  IM    
Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, New Orleans, LA 70121, USA.
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MeSH Terms
Carcinoid Heart Disease / complications*,  diagnosis,  therapy
Diagnosis, Differential
Heart Failure / diagnosis,  etiology*
Tricuspid Valve Insufficiency / diagnosis,  etiology*

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