Document Detail

Isolated systolic hypertension from a vascular point of view.
MedLine Citation:
PMID:  11146402     Owner:  NLM     Status:  MEDLINE    
Due to the results of antihypertensive intervention studies, isolated systolic hypertension (ISH) has gained new interest lately. Yet, apart from increased aortic stiffness, the specific pathophysiological features of ISH have remained largely undetermined. Therefore, we investigated the elastic properties of the vascular bed of an upper arm segment in uncomplicated ISH patients and matched normotensive controls using an electrical bioimpedance technique. Compared with the controls, the compliance of the arterial bed as a whole at normotensive blood pressure level was on the average 108.0% higher (p < 0.005) in the hypertensive patients. The blood volume of the arterial bed as a whole at operating blood pressure level and that of the larger arteries were significantly higher (40.5%, p < 0.05, and 40.5%, p < 0.01, respectively). The same held true for the venous blood volume (64.4%, p < 0.05), and for the width of the arterial compliance-pressure relation (34.6%, p < 0.01). We concluded that ISH is a separate pathophysiological entity in which all parts of a peripheral vascular bed are changed and the decreased buffering function of the aorta and large arteries is partly compensated for by an increase in small artery compliance.
J H Muntinga; W F Heesen; A J Smit; K R Visser; J F May
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular research     Volume:  37     ISSN:  1018-1172     ISO Abbreviation:  J. Vasc. Res.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  485-93     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Department of Medical Physiology, University of Groningen, Groningen, The Netherlands.
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MeSH Terms
Aged, 80 and over
Aging / physiology
Aorta / physiopathology
Arm / blood supply
Arteries / physiopathology*
Blood Pressure
Blood Volume
Electric Impedance
Hypertension / physiopathology*
Middle Aged
Systole / physiology*
Vascular Capacitance
Vascular Resistance
Veins / physiopathology*
Venous Pressure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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