| Isolated swine heart ventricle perfusion model for implant assisted-magnetic drug targeting. | |
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MedLine Citation:
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PMID: 18573319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An isolated swine heart ventricle perfusion model was developed and used under physiologically relevant conditions to study implant assisted-magnetic drug targeting (IA-MDT). A stent coil was fabricated from a ferromagnetic SS 430 wire and used to capture 100-nm diameter magnetite particles that mimicked magnetic drug carrier particles (MDCPs). Four key cases were studied: (1) no stent and no magnet (control), (2) no magnet but with a stent, (3) no stent but with a magnet (traditional MDT), and (4) with a stent and a magnet (IA-MDT). When applied, the magnetic field was fixed at 0.125T. The performance of the system was based on the capture efficiency (CE) of the magnetite nanoparticles. The experiments done in the absence of the magnetic field showed minimal retention of any nanoparticles whether the stent was present or not. The experiments done in the presence of the magnetic field showed a statistically significant increase in the retention of the nanoparticles, with a marked difference between the traditional and IA-MDT cases. Compared to the control case, in one case there was nearly an 11-fold increase in CE for the IA-MDT case compared to only a threefold increase in CE for the traditional MDT case. This enhanced performance by the IA-MDT case was typical of all the experiments. Histology images of the cross-section of the coronary artery revealed that the nanoparticles were captured mainly in the vicinity of the stent. Overall, the IA-MDT results from this work with actual tissue were very encouraging and similar to those obtained from other non-tissue and theoretical studies; but, they did point to the need for further studies of IA-MDT. |
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Authors:
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Misael O Avilés; Jan O Mangual; Armin D Ebner; James A Ritter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-06-23 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 361 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-10-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 202-8 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, Swearingen Engineering Center, University of South Carolina, Columbia, SC 29208, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Vessels / metabolism Disease Models, Animal Drug Delivery Systems / methods* Ferric Compounds / chemistry Ferrosoferric Oxide / chemistry Heart Ventricles / metabolism* Magnetics* Nanoparticles Prostheses and Implants Stents Swine |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 1317-54-0/ferrite; 1317-61-9/Ferrosoferric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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