| Isolated small bowel perforation following intrauterine treatment with indomethacin. | |
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MedLine Citation:
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PMID: 7945625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Indomethacin, a prostaglandin synthetase inhibitor, is an effective tocolytic agent that may have adverse fetal side effects such as constriction of the ductus arteriosus, pulmonary hypertension, and reduced urine production. We describe an unusual neonatal complication following 6 days of tocolysis with indomethacin. A 22-year-old gravida 5, para 3104 was admitted at 25 weeks of gestation in labor. Attempts to stop labor using magnesium sulfate and terbutaline failed. The contractions stopped following the administration of indomethacin, which was continued for 6 days. On day 7, due to contractions and vaginal bleeding, she underwent a classic cesarean section. The female newborn, weighting 1044 g, did well for 2 days, when she developed pneumoperitoneum. On laparotomy, an isolated midileal perforation was found, with otherwise normal-appearing bowel. Isolated intestinal perforation has been described in premature neonates who were treated with indomethacin for patent ductus arteriosus. This complication is caused by splanchnic ischemia secondary to the loss of the vasodilatory effect of prostaglandins. This case indicates that this rare but serious complication may also follow intrauterine exposure to indomethacin. |
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Authors:
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M D Fejgin; M L Delpino; K S Bidiwala |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of perinatology Volume: 11 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-12-02 Completed Date: 1994-12-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 295-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Michael Reese Medical Center, Chicago, Illinois. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Diseases / chemically induced* Humans Ileal Diseases / chemically induced* Indomethacin / adverse effects*, therapeutic use Infant, Newborn Intestinal Perforation / chemically induced* Pregnancy Tocolysis* |
| Chemical | |
Reg. No./Substance:
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53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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