Document Detail

Isolated pontine infarcts: etiopathogenic mechanisms.
MedLine Citation:
PMID:  16324092     Owner:  NLM     Status:  MEDLINE    
Although there are several clinico-topographical studies of pontine infarcts, few include vascular studies. To clarify the etiopathogenic mechanisms of pontine infarcts we analyzed the vascular findings and their association with MRI lesions. The clinical features and vascular findings on transcranial Doppler (TCD) or MR angiography (MRA) of 67 patients with acute infarcts involving the pons were studied. Functional outcome was assessed by modified Rankin Scale (mRS) scores on admission and 2 months later. Two groups of isolated pontine infarcts were found on the basis of lesion location on MRI, according to the extent or not to the anterior surface of the pons: paramedian pontine infarcts (PPI, n = 36) and lacunar pontine infarcts (LPI, n = 31). Hypertension was the most common vascular risk factor and pure motor syndrome was the most frequent clinical profile in both groups. Basilar artery stenosis found on TCD or MRA was significantly more frequent amongst the PPI group (P < 0.05). On admission and 2 months later, the mRS scores of the PPI group were significantly worse (P < 0.0001) than those of the LPI group. Patients with PPI have a significantly higher frequency of basilar artery stenosis and they have a worse prognosis than patients with LPI.
M E Erro; J G?llego; M Herrera; B Bermejo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  12     ISSN:  1351-5101     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  984-8     Citation Subset:  IM    
Unidad de Ictus, Servicio de Neurolog?a, Hospital de Navarra, Pomplona, Spain.
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MeSH Terms
Blood Vessels / pathology
Brain Infarction / etiology*,  pathology*,  physiopathology
Diabetes Complications
Hypertension / complications
Magnetic Resonance Angiography
Pons / pathology*,  radiography
Retrospective Studies
Risk Factors
Ultrasonography, Doppler, Transcranial
Vertebrobasilar Insufficiency / complications,  epidemiology

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