| Isolated pharmacomechanical thrombolysis plus primary stenting in a single procedure to treat acute thrombotic superior vena cava syndrome. | |
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MedLine Citation:
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PMID: 20199277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report a combined procedure that opens the acutely thrombosed superior vena cava (SVC) to rapidly alleviate symptoms in seriously ill patients with SVC syndrome. CASE REPORTS: Four patients aged 54 to 63 years old with underlying malignancies were referred for treatment of SVC syndrome. All received isolated pharmacomechanical thrombolysis (IPMT) with tissue plasminogen activator delivered in a Trellis Peripheral Infusion System that removed obstructive clot in minutes versus the 24 to 48 hours required for traditional catheter-directed thrombolysis. In each case, stents were inserted immediately following IPMT in a combined procedure lasting <1 hour. Patients exhibited near-immediate relief of debilitating symptoms; completion venography demonstrated patent vessels with excellent blood flow. CONCLUSION: Combining IPMT with immediate stenting during the same session is an effective method for managing acute thrombotic SVC syndrome and limiting the exposure time and number of interventions performed on seriously ill patients. |
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Authors:
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Gerard J O'Sullivan; Jennifer Ni Mhuircheartaigh; David Ferguson; Eithne Delappe; Conor O'Riordan; Ann Michelle Browne |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists Volume: 17 ISSN: 1545-1550 ISO Abbreviation: J. Endovasc. Ther. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-04 Completed Date: 2010-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896915 Medline TA: J Endovasc Ther Country: United States |
Other Details:
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Languages: eng Pagination: 115-23 Citation Subset: IM |
Affiliation:
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Section of Interventional Radiology, Department of Radiology, and, University College Hospital, Newcastle Road, Galway, Ireland. gerard.osullivan2@hse.ie |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon
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instrumentation* Anticoagulants / therapeutic use Combined Modality Therapy Constriction, Pathologic Edema / etiology, therapy Equipment Design Female Fibrinolytic Agents / administration & dosage* Heparin, Low-Molecular-Weight / therapeutic use Humans Male Middle Aged Neoplasms / complications* Phlebography Recurrence Stents* Superior Vena Cava Syndrome / etiology, physiopathology, radiography, therapy* Thrombectomy / instrumentation* Thrombolytic Therapy* / instrumentation Time Factors Tissue Plasminogen Activator / administration & dosage* Treatment Outcome Vascular Patency |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Fibrinolytic Agents; 0/Heparin, Low-Molecular-Weight; EC 3.4.21.68/Tissue Plasminogen Activator |
| Comments/Corrections | |
Comment In:
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J Endovasc Ther. 2010 Feb;17(1):124-5
[PMID:
20199278
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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