| Isolated perfusion of pancreas with mitomycin C. | |
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MedLine Citation:
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PMID: 1693475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current treatment of pancreatic cancer with resection and/or radiation is considered unsatisfactory because of a high incidence of failure and a moderate incidence of complications. A sizable number of these patients present with localized or regional disease. Regional high-dose chemotherapy, such as with isolated perfusion, may offer an alternative therapy with low treatment-related morbidity and mortality and better end results in this group of patients. In an effort to develop such a treatment modality, we evaluated the pharmacokinetics and toxicity of mitomycin C (MMC) during isolated perfusion of pancreas in a canine model. From this study, it appears that a dose of 0.25 mg MMC/kg body weight is most suitable for isolated perfusion of pancreas at 39 degrees C, maintaining flow rate and pressure within physiologic range. Isolated perfusion with a dose of 0.25 mg/kg body weight has very mild short- and long-term toxicities and markedly increases drug delivery to the pancreas, duodenum, and peripancreatic lymph nodes, making it the most suitable dose for possible clinical application. |
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Authors:
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M A Arredondo; B Chaudhuri; R Kar; K A Crist; N R Thomford; P K Chaudhuri |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of surgery Volume: 159 ISSN: 0002-9610 ISO Abbreviation: Am. J. Surg. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-07-06 Completed Date: 1990-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 569-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Medical College of Ohio, Toledo 43699-0008. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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blood Animals Blood Glucose / analysis Chemotherapy, Cancer, Regional Perfusion* Chromatography, High Pressure Liquid Dogs Duodenum / metabolism Leukocyte Count Lipase / blood Lymph Nodes / metabolism Male Mitomycin Mitomycins / administration & dosage*, pharmacokinetics, toxicity Pancreas* / metabolism Pancreatic Neoplasms / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Mitomycins; 50-07-7/Mitomycin; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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