| Isolated mitral valve prolapse: chordal architecture as an anatomic basis in older patients. | |
MedLine Citation:
|
PMID: 3998315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ten patients with an average age of 58 years underwent valve replacement because of isolated mitral valve prolapse with severe regurgitation. None had clinical evidence of Marfan's syndrome or another systemic disease that would indicate that a primary connective tissue disorder was the cause of the prolapse. All 10 patients had a dome configuration of the posterior leaflet and one or more ruptured chordae related to it. The gross morphology of the resected specimens revealed marked deviations in chordal branching and the pattern of anchoring in each of the 10 cases, rendering the most severely affected parts of the leaflets less well supported. Similar changes occurred at sites remote from the principal abnormality. Microscopically, the dominant tissue change was myxomatous transformation within the affected leaflets and chordae with secondary changes at both atrial and ventricular surfaces. These findings could indicate that insufficient chordal support may have promoted the development of the floppy valve through a process of chronic undue and unbalanced stress on the valve tension and closure apparatus. The resultant degeneration of the connective tissues, histologically expressed as myxomatous transformation, may underlie stretching and thus redundance of the leaflets and eventually rupture of chordae. It is suggested that this sequence of events be considered as a possible pathogenetic mechanism of isolated mitral valve prolapse, particularly in the subset of aged patients. |
Authors:
|
J van der Bel-Kahn; D R Duren; A E Becker |
Related Documents
:
|
17363095 - Mitral valve prolapse and sudden deafness. 2612075 - Systolic tricuspid leaflet prolapse in asymptomatic young men. 23948595 - Suppression of cyclin d1 by plasmid-based short hairpin rna ameliorated experimental pu... 3205165 - Mitral valve prolapse (barlow's syndrome) and retinal emboli. 25306065 - Management of acute type b aortic dissection; adsorb trial. 24982115 - Healthy lifestyle change and subclinical atherosclerosis in young adults: coronary arte... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 5 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1985 Jun |
Date Detail:
|
Created Date: 1985-07-10 Completed Date: 1985-07-10 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1335-40 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Aged Chordae Tendineae / pathology* Female Heart Valve Diseases / pathology Heart Valve Prosthesis Humans Male Middle Aged Mitral Valve / pathology*, surgery Mitral Valve Prolapse / pathology*, surgery Myocardium / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carotid sinus reflex control of coronary blood flow in human subjects.
Next Document: Primary (spontaneous) chordal rupture: relation to myxomatous valve disease and mitral valve prolaps...