Document Detail

Isolated low second-trimester maternal serum beta-human chorionic gonadotropin is not associated with adverse pregnancy outcome.
MedLine Citation:
PMID:  14526308     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated whether low human chorionic gonadotropin from maternal serum screening is associated with adverse pregnancy outcome. STUDY DESIGN: Women between 15 and 20 completed weeks of gestation who had a maternal serum screen performed from June 1999 to November 2001 were studied. Cases included women with human chorionic gonadotropin values of <or=0.5 multiples of the median, alpha-fetoprotein values of >0.5 and <2.0 multiples of the median, and estriol values of >0.6 and <2.0 multiples of the median. Control subjects were selected randomly from the population of women with normal values for all three analytes. RESULTS: There were 146 case subjects and 292 control subjects. There was no increased risk in the study group compared with the control subjects for preterm delivery, intrauterine fetal death, low birth weight, abruptio placentae, preeclampsia, or preterm premature rupture of membranes. CONCLUSION: An isolated low human chorionic gonadotropin level from second-trimester maternal serum screening is not associated with adverse pregnancy outcome.
Loraine K Endres; Stephan Krotz; William A Grobman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  189     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-03     Completed Date:  2003-11-04     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Northwestern University, Chicago, Ill., USA.
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MeSH Terms
Abruptio Placentae / epidemiology
Birth Weight
Chorionic Gonadotropin, beta Subunit, Human / blood*
Estriol / blood
Fetal Death / epidemiology
Fetal Membranes, Premature Rupture / epidemiology
Gestational Age*
Infant, Newborn
Obstetric Labor, Premature / epidemiology
Pre-Eclampsia / epidemiology
Pregnancy Outcome*
Pregnancy Trimester, Second
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins; 50-27-1/Estriol

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