| Isolated itching of external auditory canal: clinicopathological study with immunohistochemical determination of antimicrobial peptides. | |
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MedLine Citation:
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PMID: 21029502 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective:This study aimed to demonstrate the histological and immunohistological features of skin biopsy specimens from patients complaining of isolated itching of the external auditory canal.Materials and methods:A prospective, case-control study was performed of 24 patients undergoing evaluation for contact dermatitis of the external auditory canal, and 24 controls. Skin biopsies were examined histologically by a single, blinded dermatopathologist, using light microscopy, to determine histopathological characteristics. The immunohistological presence of the antimicrobial peptides human β-defensin-3 and LL-37 cathelicidin was also assessed. Findings for patients and controls were compared.Results:There was a statistically significant difference in the degree of inflammation, comparing patients and controls (p < 0.05). There was no significant difference in the presence of spongiotic changes, comparing patients and controls (p > 0.05). Furthermore, the patients' skin biopsies did not show pronounced expression of human β-defensin-3 or LL-37 cathelicidin.Conclusion:Histological and immunohistological examination of skin biopsies from cases of isolated itching of the external auditory canal did not support a diagnosis of dermatitis. |
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Authors:
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B Acar; G Güler Simsek; S Oguztuzun; M Zaim; R Murat Karasen |
Publication Detail:
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Type: Journal Article Date: 2010-10-29 |
Journal Detail:
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Title: The Journal of laryngology and otology Volume: 125 ISSN: 1748-5460 ISO Abbreviation: J Laryngol Otol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706896 Medline TA: J Laryngol Otol Country: England |
Other Details:
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Languages: eng Pagination: 227-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Otorhinolaryngology, Kecioren Training and Research Hospital, Ankara, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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